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Concept Map Tuberculosis Infection โ Tuberculosis Concept Map | Deanne Blach DB Productions: Concepts of one kind or another have been around since at least the 1930s. Many remain in the public memory for years, but most are quickly forgotten as soon as a new batch turns up. For example . The loop extrusion hypothesis has shaped current thinking about chromatin organization by SMC complexes. This article experimentally tests the hypothesis, with a negative outcome, and puts forward .